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I ran the Prague Half last year. Mostly flat course taking in the sights of Prague. My only concern was some stretches of cobble stones. That aside a tremendous event.
Michelle, there's another thread started for the 2013 Prague Half on here - started December 2012. There's a bit of info there about the course if it helps.
I got an email with my bib number this week. It's not too far away now... looking forward to it.