My GP started me on a trial of a thiazide diuretic for slightly raised BP (long story)about a month ago. During this time I have developed what my physio thinks may be compartment syndrome in both anterior compartments in my lower legs. Is this coincidence? I notice one of the side effects listed is muscle cramps/weakness. Common sense tells me it's two different things, but now I can't run and as some of you know running is a major de-stressor for me (lifts mood, time away from autistic son, helping with recent bereavement etc) I am sooooo fed up! I have also had to start taking norithesterone too. I seem to have gone from feeling healthy-no meds to feeling shite-loads of meds in about 2 months! Any suggestions?