Sudden loss of desire to run at about 18 miles

Today I experienced a complete loss of desire to run at the 18 mile mark of my long slow run. I was in really good shape until 16 miles when I started to feel a bit tired. At 18 miles though I had this very strong desire to just stop. I took a 1 min break and stretched. I got running again. My legs were tired but felt good for a few more miles. However, at mile 20 I just wanted to stop again. And I did stop. 

Does this sound like it is a nutrition issue, a lack of will power, lack of physical fitness or something else? Not sure what to do about it. 

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