knee pain

Having changed trainers from Air Kantra to Mizuno Legend I have experienced pain on the inside and underneath the kneecap area .originally started after a 16 mile run and despite r,i,c,e + iboprufen no improvement felt and reoccurs at 3-4 mile stage.
Has anyone any ideas as the cause or how to treat this injury. Is it shoe related or a co-incidental injury

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